2-Aminothiazole → HCID 25138300, compound

Participants

Reaction Steps

To 4-[2-(4-Trifluoromethyl-phenyl)-ethanesulfonyl]-benzenesulfonyl chloride (1288 mg, 0.003120 mol) and 2-aminothiazole (0.31 g, 0.0031 mol) was added pyridine (20 mL). After stirring overnight, the reaction mixture was concentrated, dissolved in DMSO (4 mL) and purified by reversed phase chromatography (Phenomenex 250×30 mm 15 micron C18 column. 40 mL/min. Gradient 85% A to 100% B over 25 min. Solvent A: 7800 water/200 acetonitrile/8 TFA. Solvent B: 7200 acetonitrile/800 water/8 TFA). The compound was further purified on silica gel (CHCl3-10% MeOH in CHCl3) to give 94 mg of a light brown solid. LCMS: M+477.

Provenance & Evidence