HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → 2-(1H-indol-3-yl)-2-oxo-N-(2-phenylethyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | 3-Indoleglyoxylyl chloride | HCID 89952 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-(1H-indol-3-yl)-2-oxo-N-(2-phenylethyl)acetamide | HCID 2176767 | — |
Reaction Steps
2-(1H-Indol-3-yl)-2-oxo-N-phenethyl-acetamide was synthesized following scheme I above starting from (1H-indol-3-yl)-oxo-acetyl chloride and phenethylamine. Yield (61%). HPLC ret. time 3.17 min, 10-99% CH3CN, 5 min run; 1H NMR (400 MHz, DMSO-d6) δ 12.23 (s, 1H), 8.79 (t, J=5.9 Hz, 1H), 8.67 (s, 1H), 8.23 (m, 1H), 7.53 (m, 1H), 7.33-7.19 (m, 7H), 3.47 (m, 2H), 2.85 (t, J=7.4 Hz, 2H); ESI-MS 293.3 m/z (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853254B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-33da839e7624485e8582a08c0cc4472c |
| Source note | uspto-grants-2014_10 |