HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylbenzylamine → N-Benzyl-2-(1H-indol-3-yl)-N-methyl-2-oxo-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylbenzylamine | HCID 7669 | — |
| Reactant | 3-Indoleglyoxylyl chloride | HCID 89952 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-Benzyl-2-(1H-indol-3-yl)-N-methyl-2-oxo-acetamide | HCID 288389 | — |
Reaction Steps
N-Benzyl-2-(1H-indol-3-yl)-N-methyl-2-oxo-acetamide was synthesized following scheme I above starting from (1H-indol-3-yl)-oxo-acetyl chloride and benzyl-methyl-amine. Yield (54%). HPLC ret. time 2.96 min, 10-99% CH3CN, 5 min run; 1H NMR (400 MHz, DMSO-d6) δ 12.35 (s, 1H), 8.25 (s, 0.5H), 8.13-8.11 (m, 1.5H), 7.54 (m, 1H), 7.44-7.23 (m, 7H), 4.68 (s, 1H), 4.47 (s, 1H), 2.88 (s, 1.5H), 2.85 (s, 1.5H); ESI-MS 293.3 m/z (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853254B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-2054f56d00f946d3bbd83fc326022bf3 |
| Source note | uspto-grants-2014_10 |