Acetic Acid → HCID 178497092, compound

HRID 533415Notes

Reaction equation

HRID 533415 reaction equation
[Br:1]Br.C(O)(=O)C.[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]([O:20][CH3:21])=[O:19])[CH:16]=2)[CH:11]=[CH:10][N:9]=1>O>[Br:1][C:11]1[C:12]2[C:17](=[CH:16][C:15]([C:18]([O:20][CH3:21])=[O:19])=[CH:14][CH:13]=2)[C:8]([OH:7])=[N:9][CH:10]=1

Participants

5

Reactant 3

HCID 176Acetic Acid2×HCID 24408BromineHCID 178497278HCID 178497278, compound

Product 1

HCID 178497092HCID 178497092, compoundYield 84.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of bromine (940 mg) and acetic acid (10 mL) was added dropwise to a mixture of methyl 1-hydroxyisoquinoline-7-carboxylate (1.2 g) and acetic acid (50 mL) and stirred at room temperature for 30 minutes. The reaction mixture was diluted with water, and the precipitate was collected by filtration to obtain methyl 4-bromo-1-hydroxyisoquinoline-7-carboxylate (1.4 g).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-34e21cb7b6ee441e89b720620fec73c6
Source dataset
uspto-grants-2014_10
Patent number
US08853242B2

Reaction notes

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