Methanol → HCID 67776040, compound

HRID 533420Notes

Reaction equation

HRID 533420 reaction equation
S(=O)(=O)(O)O.[CH3:6][C:7]1[O:8][C:9](=[O:20])[C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([C:17]([O-:19])=[O:18])[CH:11]=2.[Na+].[CH3:22]O>O>[CH3:6][C:7]1[O:8][C:9](=[O:20])[C:10]2[C:15]([CH:16]=1)=[CH:14][CH:13]=[C:12]([C:17]([O:19][CH3:22])=[O:18])[CH:11]=2

Participants

5

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 67773554HCID 67773554, compound

Product 1

HCID 67776040HCID 67776040, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

Concentrated sulfuric acid (3 mL) was added to a mixture of sodium 3-methyl-1-oxo-1H-isochromene-7-carboxylate (1.69 g) and methanol (50 mL), and heated under stirring in an oil bath at 60° C. for 2 days. The reaction mixture was returned to room temperature, diluted with water, and extracted with ethyl acetate. The organic layer was washed with water, dried, and concentrated under reduced pressure to obtain methyl 3-methyl-1-oxo-1H-isochromene-7-carboxylate (1.0 g).

Workup

  1. temperatureheated
  2. customwas returned to room temperature
  3. extractionextracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. customdried
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-807ccc219db249bf93def85f1dce21d3
Source dataset
uspto-grants-2014_10
Patent number
US08853242B2

Reaction notes

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