Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2,2-Dimethyl-1,3-dioxane-4,6-dione | HCID 16249 | — |
| Reactant | 4-Amino-3-methylbenzoic acid | HCID 75598 | — |
| Reactant | Methylorthoformate | HCID 53629101 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67774099 | HCID 67774099 | 68.5% |
Reaction Steps
A mixture of 4-amino-3-methylbenzoic acid (7.3 g), Meldrum's acid (7.3 g), methyl orthoformate (5.6 g) and methanol (30 mL) was heated under stirring in an oil bath at 60° C. for 5 hours. The reaction mixture was returned to room temperature, diluted with ethyl acetate and the precipitate was collected by filtration to obtain 4-{[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methyl]amino}-3-methylbenzoic acid (10.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853242B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-5d9c512a5c984526bb19d1f42ae4bc7a |
|---|
| Source note | uspto-grants-2014_10 |
|---|
