HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 533477Generated: October 28, 2026
p-Toluenesulfonic acid → 2-(3-Acetamidophenylamino)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxamide
https://huagongshe.com/reaction/533477
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | m-Aminoacetanilide | HCID 7604 | — |
| Reactant | 2-(Methylsulfinyl)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxamide | HCID 58098785 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-(3-Acetamidophenylamino)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxamide | HCID 58098740 | 59% |
Reaction Steps
To a solution of 2-(methylsulfinyl)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxamide (50 mg, 0.16 mmol) in NMP (1 mL) was added 3-acetamidoaniline (27 mg, 0.18 mmol) and pTsOH*H2O (30 mg, 0.16 mmol). The mixture was heated at 100° C. for 2 h, cooled to room temperature, and purified by preparative HPLC to give 2-(3-acetamidophenylamino)-4-(1-phenylcyclopropylamino)pyrimidine-5-carboxamide (38 mg). MS found for C22H22N6O2 as (M+H)+ 403.5. λ=251.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853230B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-e4f279e7341c450795023278280256d6 |
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| Source note | uspto-grants-2014_10 |
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