(S)-1-methyl-N-(3-nitrophenyl)pyrrolidine-2-carboxamide → HCID 58098798, compound

HRID 533479Notes

Reaction equation

HRID 533479 reaction equation
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([N+:16]([O-])=O)[CH:11]=1)=[O:8]>CO.[Pd]>[NH2:16][C:12]1[CH:11]=[C:10]([NH:9][C:7]([C@@H:3]2[CH2:4][CH2:5][CH2:6][N:2]2[CH3:1])=[O:8])[CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 1

HCID 58098896(S)-1-methyl-N-(3-nitrophenyl)pyrrolidine-2-carboxamide

Product 1

HCID 58098798HCID 58098798, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of (S)-1-methyl-N-(3-nitrophenyl)pyrrolidine-2-carboxamide (crude from step 1) in MeOH (5 ml) was added Pd/C (50 mg), charged with H2 (1 atm), after stirring for 3 h, Pd/C was filtered off and the filtrate was concentrated to give (S)—N-(3-aminophenyl)-1-methylpyrrolidine-2-carboxamide (350 mg).

Workup

  1. additioncharged with H2 (1 atm)
  2. filtrationPd/C was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-317fdf79792a4c35a7994a309b838006
Source dataset
uspto-grants-2014_10
Patent number
US08853230B2

Reaction notes

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