反应详情

温度

80 °C

4-Methyl benzophenone (product of Aldrich) (25.1 parts), N-bromo succinimide [product of Wako Pure Chemical industries, Ltd.] (22.8 parts), benzoyl peroxide [water content: 20%, product of Wako Pure Chemical Industries, Ltd.] (0.54 parts), and acetonitrile (80 parts) were mixed, heated to 80° C., and allowed to react for 2 hours under reflux. Subsequently, the resulting mixture was cooled, and the organic solvent was evaporated under reduced pressure. The residue was recrystallized in methanol (160 parts). As a result, 26 parts of an intermediate (C123-6-1) was obtained (as white crystals).

1. customto react for 2 hours
2. temperatureunder reflux
3. temperatureSubsequently, the resulting mixture was cooled
4. customthe organic solvent was evaporated under reduced pressure
5. customThe residue was recrystallized in methanol (160 parts)
6. customAs a result, 26 parts of an intermediate (C123-6-1) was obtained (as white crystals)