HRID5335

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID712

Formaldehyde

CH2O

HCID6106

L-Leucine

C6H13NO2

HCID83170

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

C11H21NO4

PRODUCTS

生成物

HCID83170

L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-

C11H21NO4

HCID104275

1,1-Dimethylethyl N-[(1S)-1-formyl-3-methylbutyl]carbamate

C11H21NO3

结构：CC(C)(C)OC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)O

HCID44424848

未命名化合物

PROCEDURE

实验过程

Leu-psi -Tpi-BHA resin is made by reacting Boc-Leu-psi -Trp-BHA resin with formaldehyde in accordance with the procedures as follows: Boc-Leu-psi -Trp-BHA resin is obtained from 1.0 g BHA resin (0.9 m mode NH2 g) with coupling Boc-Trp and Boc-Leu-CHO successively by the method indicated in Operation I and Operation II. 10 ml. DMF containing 1% acetic acid is added to the above peptide resin and then reacted with 1 ml 10% formaldehyde at room temperature for 60 minutes and washed with DMF, MeOH and DCM.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-918dffba71544237accb80156ad6bdb6
来源数据集: uspto-grants-1993_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05244883
来源说明: uspto-grants-1993_09

反应 SMILES

[NH2:1][C@H:2]([C:7](O)=O)[CH2:3][CH:4]([CH3:6])C.[NH:10]([C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14].[CH2:26]=O>>[NH:10]([C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14].[CH3:25][C:22]([O:21][C:19]([NH:10][C@H:11]([C:16]([OH:18])=[O:17])[CH2:12][C:13]1[NH:1][C:2]2[CH:3]=[CH:4][CH:6]=[CH:26][C:7]=2[CH:15]=1)=[O:20])([CH3:23])[CH3:24].[NH:10]([C:19]([O:21][C:22]([CH3:24])([CH3:23])[CH3:25])=[O:20])[C@H:11]([CH:16]=[O:17])[CH2:12][CH:13]([CH3:15])[CH3:14]