HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → 4-(4-Bromo-2-methylphenyl)-2-methyl-2-(methylsulfonyl)butanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | (+/-)-4-(4-Bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid | HCID 66577906 | — |
| Reactant | 4-(4-Bromo-2-methyl-phenyl)-2-methanesulfonyl-2-methyl-butyric acid ethyl ester | HCID 66578032 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Bromo-2-methylphenyl)-2-methyl-2-(methylsulfonyl)butanoic acid | HCID 66577933 | — |
Reaction Steps
The title compound was synthesized according to the general procedure of Preparation Number 2, Step 3, for the preparation of (II) except that 4-(4-bromo-2-methyl-phenyl)-2-methanesulfonyl-2-methyl-butyric acid ethyl ester was used instead of (+/−)-ethyl 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoate and that the lithium hydroxide was dissolve in water prior to addition. Yield: 3.259 (81.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853258B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-af1273a85eff41ab847c9b53793c7435 |
| Source note | uspto-grants-2014_10 |