Phenylboronic Acid → N-Hydroxy-2-methyl-2-(methylsulfonyl)-4-(5-phenylpyridin-2-yl)butanamide

Participants

Reaction Steps

The title compound (2 mg, 1%) was prepared from 4-(5-bromopyridin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide (151 mg, 0.43 mmol) and phenylboronic acid (79 mg, 0.65 mmol) by a procedure analogous to that described in Step F of Example 3. LCMS m/z 349.4 (M+1). 1H NMR (400 MHz, CD3OD) δ 1.68 (s, 3H), 2.25 (m, 1H), 2.66-2.82 (m, 2H), 2.95 (m, 1H), 3.08 (s, 3H), 7.38-7.51 (m, 4H), 7.63-7.66 (m, 2H), 8.02 (dd, J=8.1, 2.3 Hz, 1H), 8.71 (dd, J=2.4, 0.8 Hz, 1H).

Provenance & Evidence