1-Bromo-4-(2-iodoethyl)benzene → 4'-Fluoro-4-(2-iodoethyl)-2-methoxybiphenyl

HRID 533567Notes

Reaction equation

HRID 533567 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15]O)=[CH:10][C:9]=2[O:17][CH3:18])=[CH:4][CH:3]=1.BrC1C=CC(CC[I:28])=CC=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][I:28])=[CH:10][C:9]=2[O:17][CH3:18])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 197022221-Bromo-4-(2-iodoethyl)benzeneHCID 665779462-(4'-Fluoro-2-methoxybiphenyl-4-yl)ethanol

Product 1

HCID 665779354'-Fluoro-4-(2-iodoethyl)-2-methoxybiphenylYield 74.5%

Procedure

The title compound (549 mg, 74.5%) was prepared from 2-(4′-fluoro-2-methoxybiphenyl-4-yl)ethanol (which may be made as described in Preparation Number 5) following the general procedure described in Preparation 2, Step 1 for 1-bromo-4-(2-iodoethyl)benzene. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 3.11 (t, J=8.00 Hz, 2H) 3.33 (t, J=7.81 Hz, 2H) 3.90 (s, 3H) 6.66-6.73 (m, 4H) 6.87 (d, J=8.59 Hz, 2H) 7.27 (s, 1H).

Sources & evidence

ORD record
ord-417b301354fa4e968fd1d51cc7fd699f
Source dataset
uspto-grants-2014_10
Patent number
US08853258B2

Reaction notes

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