反应详情

A mixture of ethyl(methylsulphonyl)acetate (330 mg, 1.99 mmol) in 4 mL of DMF was treated with sodium hydride (88 mg, 60% dispersion in mineral oil, 2.19 mmol), until effervescence ceased in an ice bath under nitrogen. To this was added 4-fluoro-4′-(2-iodoethyl)biphenyl (650 mg, 1.99 mmol) as a solid and the residual material was dissolved by the addition of DMF (2 mL). The mixture was warmed to room temperature, then heated at 50° C. for 2 hours. The mixture was then cooled to room temperature, poured into 60 mL of 0.5N aqueous HCl and extracted 2×60 mL with ethyl acetate. The organic phase was dried over sodium sulfate filtered and concentrated in vacuo to yield a light yellow oil with some white solid particulates. The crude yield was 840 mg. The material was purified by flash chromatography on a 40 mm flash column using 120 g silica gel eluting with 0-50% ethyl acetate/heptane. This afforded the title compound as an oil (510 mg, 70.2%). MS (LC/MS) m/z 365.2 (M+1).

1. customceased in an ice bath under nitrogen
2. temperatureheated at 50° C. for 2 hours
3. temperatureThe mixture was then cooled to room temperature
4. extractionextracted 2×60 mL with ethyl acetate
5. dry with materialThe organic phase was dried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto yield a light yellow oil with some white solid particulates
9. customThe material was purified by flash chromatography on a 40 mm flash column