(2-Chloro-6-nitro-4-trifluoromethylphenyl)-methylamine → 3-Chloro-N2-methyl-5-(trifluoromethyl)-1,2-benzenediamine

Participants

Reaction Steps

To a mixture of (2-chloro-6-nitro-4-trifluoromethylphenyl)-methylamine (3.70 g) and ethanol (60 ml), Raney® nickel (slurry in water, 0.5 ml) was added, and stirred under about 1 atm of hydrogen at room temperature for 1.5 hours. The reaction mixture was filtered. The filtrate was concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography to give 2.95 g of 3-chloro-N2-methyl-5-trifluoromethylbenzene-1,2-diamine.

Provenance & Evidence