HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen iodide → N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl)valeramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | Benzenepropanamide, beta-ethyl-3-methoxy-N,N,alpha-trimethyl- | HCID 67306944 | — |
| Product | N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl)valeramide | HCID 67478908 | — |
Reaction Steps
The steps are: add compound 7 into a reaction flask, add hydroiodic acid, perform heating and reflux for 5 hours; detect the reaction process by TLC; after that, cool the resultant to the room temperature, pour it to an alkaline solution to make the pH become 9, and perform extraction by ethyl acetate and rinse by water; and recycle the solvent after drying and decompression to obtain a light yellow liquid, N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl) valeramide (compound 9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853393B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-c2f9223da66744f39d6b3ee893b1c5ed |
| Source note | uspto-grants-2014_10 |