HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Lurasidone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86731815 | HCID 86731815 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Lurasidone hydrochloride | HCID 11237860 | — |
Reaction Steps
A mixture consisting of acetone (3450 mL) and lurasidone oxalate (432 g) is refluxed until dissolved. Concentrated hydrochloric acid (68 mL) is added, and the mixture is cooled to ambient temperature, and then cooled for three hours at 5° C. The solid is filtered, and 326 g of lurasidone hydrochloride free of impurities exceeding 0.1% is obtained after drying.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853395B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-72d3478bee01415d9ab72d02282b1e06 |
| Source note | uspto-grants-2014_10 |