HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → Lurasidone hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86731815 | HCID 86731815 | — |
| Solvent | Water | HCID 962 | — |
| Product | Lurasidone hydrochloride | HCID 11237860 | — |
Reaction Steps
A mixture consisting of acetone (280 mL), water (140 mL) and lurasidone oxalate (47 g) is refluxed until dissolved. Concentrated hydrochloric acid (11 mL) is added, and the mixture is cooled at ambient temperature for two hours. The solid is filtered, and 36 g of lurasidone hydrochloride free of impurities exceeding 0.1% is obtained after drying.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853395B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-fcc25adeb3eb4f8d88b7a6f66227aede |
| Source note | uspto-grants-2014_10 |