Methanol → HCID 12092493, compound

Participants

Reaction Steps

To a solution of methyl 4-(4-fluorophenylcarbamoyl)benzoate (2.98 g, 10.9 mmol) in THF (35 mL) was added MeOH (8 mL) and a solution of LiOH (1.79 g, 43.6 mmol) in H2O (8 mL). The reaction was stirred at room temperature for 2 h. The reaction was quenched upon the addition of 1N HCl (50 mL) and extracted with EtOAc (2×60 mL). The organic extracts were dried over MgSO4, and concentrated under vacuum to afford 4-(4-fluorophenylcarbamoyl)benzoic acid (2.43 g, 86%) as a white solid. 1H-nmr (400 MHz, d6-DMSO) δ 10.49 (s, 1H), 8.11-8.02 (m, 4H), 7.87-7.77 (m, 2H), 7.25-7.16 (m, 2H); MS (ESI) m/z 259.9.

Provenance & Evidence