Acetic Anhydride → HCID 46843215, compound

Participants

Reaction Steps

N-Methyl-4-(6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrol-4-yl)-benzenesulfonamide (75 mg, 0.22 mmol), acetic anhydride (22 mg, 0.22 mmol), and DIEA (0.07 mL, 0.44 mmol) were dissolved in dioxane (2.0 mL), and stirred for 2 h at room temperature. The reaction mixture was diluted with EtOAc/H2O. The resulting precipitate was filtered, washed with EtOAc, and dried under vacuum to provide 14 (40 mg, 48% yield) as a tan solid. LC-MS (M+H=385, obsd.=385).

Provenance & Evidence