2-Chlorobenzoyl chloride → HCID 46843288, compound

Participants

Reaction Steps

3-Chloro-6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrole (50 mg, 0.24 mmol) and DIEA (0.05 mL, 0.29 mmol) were dissolved in THF (2.00 ml). 2-Chlorobenzoyl chloride (0.04 mL, 0.29 mmol) was added dropwise, and the reaction mixture was stirred at room temperature for 1 h. The crude reaction mixture was concentrated, and converted to the HCl salt by dissolving the crude material in MeOH (2 ml) and adding 1 M HCl/ether (2 equiv). The resulting solution was refrigerated overnight. The resulting precipitate was filtered and dried under vacuum to provide 20 (47 mg, 51% yield) as a pale yellow solid. LC-MS (M+H=347, obsd.=347).

Provenance & Evidence