Water → HCID 46843441, compound

HRID 533751Notes

Reaction equation

HRID 533751 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[S:11](Cl)(=[O:13])=[O:12].[Cl:15][C:16]1[CH:28]=[N:27][C:19]2[NH:20][C:21]3[CH2:26][CH2:25][NH:24][CH2:23][C:22]=3[C:18]=2[CH:17]=1.O>N1C=CC=CC=1>[Cl:15][C:16]1[CH:28]=[N:27][C:19]2[NH:20][C:21]3[CH2:26][CH2:25][N:24]([S:11]([C:4]4[CH:5]=[C:6]([O:9][CH3:10])[CH:7]=[CH:8][C:3]=4[O:2][CH3:1])(=[O:13])=[O:12])[CH2:23][C:22]=3[C:18]=2[CH:17]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1370252,5-Dimethoxybenzenesulfonyl chlorideHCID 66677239HCID 66677239, compound

Product 1

HCID 46843441HCID 46843441, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2,5-Dimethoxybenzenesulfonyl chloride (63 mg, 0.26 mmol) was added to a solution of 3-chloro-6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrole (50 mg, 0.24 mmol) in pyridine (2 mL), and the reaction was stirred overnight at room temperature. The reaction mixture was added to water (20 mL), and the resulting precipitate was filtered and dried under vacuum to provide 36 (94 mg, 96% yield) as a yellow solid. LC-MS (M+H=408, obsd.=408).

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-9eaaefa3edb24778b4a782fcd1c02d3a
Source dataset
uspto-grants-2014_10
Patent number
US08853391B2

Reaction notes

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