Water → HCID 46843443, compound

HRID 533752Notes

Reaction equation

HRID 533752 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:9](Cl)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.[Cl:13][C:14]1[CH:26]=[N:25][C:17]2[NH:18][C:19]3[CH2:24][CH2:23][NH:22][CH2:21][C:20]=3[C:16]=2[CH:15]=1.O>N1C=CC=CC=1>[Cl:13][C:14]1[CH:26]=[N:25][C:17]2[NH:18][C:19]3[CH2:24][CH2:23][N:22]([S:9]([C:5]4[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=4)(=[O:11])=[O:10])[CH2:21][C:20]=3[C:16]=2[CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 27375043-Methoxybenzenesulfonyl chlorideHCID 66677239HCID 66677239, compound

Product 1

HCID 46843443HCID 46843443, compoundYield 55.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Methoxybenzenesulfonyl chloride (0.04 mL, 0.26 mmol) was added to a solution of 3-chloro-6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrole (50 mg, 0.24 mmol) in pyridine (2 mL), and the reaction was stirred overnight at room temperature. The reaction mixture was added to water (20 mL), and the resulting precipitate was filtered and dried under vacuum to provide 38 (50 mg, 55% yield) as a yellow solid. LC-MS (M+H=379, obsd.=379).

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-c9862011cf1d4c8e8031b4d8fb5bcb9d
Source dataset
uspto-grants-2014_10
Patent number
US08853391B2

Reaction notes

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