Water → HCID 46843513, compound

HRID 533754Notes

Reaction equation

HRID 533754 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([S:9](Cl)(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1)#[N:2].[Cl:13][C:14]1[CH:26]=[N:25][C:17]2[NH:18][C:19]3[CH2:24][CH2:23][NH:22][CH2:21][C:20]=3[C:16]=2[CH:15]=1.O>N1C=CC=CC=1>[Cl:13][C:14]1[CH:26]=[N:25][C:17]2[NH:18][C:19]3[CH2:24][CH2:23][N:22]([S:9]([C:5]4[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=4)[C:1]#[N:2])(=[O:11])=[O:10])[CH2:21][C:20]=3[C:16]=2[CH:15]=1

Participants

5

Reactant 3

HCID 962WaterHCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 66677239HCID 66677239, compound

Product 1

HCID 46843513HCID 46843513, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Cyanobenzenesulfonyl chloride (53 mg, 0.26 mmol) was added to a solution of 3-chloro-6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrole (50 mg, 0.24 mmol) in pyridine (2 mL), and the reaction was stirred overnight at room temperature. The reaction mixture was added to water (20 mL), and the resulting precipitate was filtered and dried under vacuum to provide 40 (68 mg, 76% yield) as a yellow solid. LC-MS (M+H=373, obsd.=373).

Workup

  1. filtrationthe resulting precipitate was filtered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-34836e8a1f394dddabf709136239da58
Source dataset
uspto-grants-2014_10
Patent number
US08853391B2

Reaction notes

Loading…