Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | P-Anisidine | HCID 7732 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | HCID 66677231 | HCID 66677231 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | 2-Methyl-2-butanol | HCID 6405 | — |
| Product | HCID 46843594 | HCID 46843594 | 3.2% |
Reaction Steps
4-Chloro-5,7,8,9-tetrahydro-dipyrido[2,3-b;3′,4′-d]pyrrole-6-carboxylic acid tert-butyl ester (100 mg, 0.32 mmol), p-anisidine (80 mg, 0.65 mmol), Pd(OAc)2 (3 mg, 0.01 mmol), X-Phos (12 mg, 0.03 mmol), and KOH (55 mg, 0.97 mmol) were suspended in tert-amyl alcohol (2 mL), and stirred overnight at 95° C. The crude product was purified directly via prep-LC-MS to provide 47 (3 mg, 3% yield) as a tan solid. LC-MS (M+H=295, obsd.=295).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853391B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-bff2061de4fd404dbe2ddfc13d263044 |
|---|
| Source note | uspto-grants-2014_10 |
|---|
