Acetic Anhydride → HCID 46843680, compound

Participants

Reaction Steps

Benzo[1,3]dioxol-5-yl-(6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrol-4-yl)-amine (50 mg, 0.16 mmol), acetic anhydride (18 μL, 0.19 mmol), and triethylamine (67 μL, 0.49 mmol) were dissolved in 1,2-dichloroethane (2 mL), and stirred overnight at room temperature. The reaction mixture was added directly to a Biotage column. The crude product was purified via Biotage eluting with a gradient of 0 to 10% MeOH in DCM. Lyophilization of the purified product provided 56 (25 mg, 44% yield) as a tan powder. LC-MS (M+H=351, obsd.=351).

Provenance & Evidence