Acetic Anhydride → HCID 46843681, compound

Participants

Reaction Steps

Naphthalen-1-yl-(6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrol-4-yl)-amine (40 mg, 0.13 mmol), acetic anhydride (12 μL, 0.13 mmol), and triethylamine (53 μL, 0.38 mmol) were dissolved in 1,2-dichloroethane (2 mL), and stirred for 3 h at room temperature. The reaction mixture was added directly to a Biotage column. The crude product was purified via Biotage eluting with a gradient of 0 to 10% MeOH in DCM. Lyophilization of the purified product provided 57 (10 mg, 22% yield) as a tan powder. LC-MS (M+H=357, obsd.=357).

Provenance & Evidence