反应详情

(4-Fluoro-phenyl)-(6,7,8,9-tetrahydro-5H-dipyrido[2,3-b;3′,4′-d]pyrrol-4-yl)-amine (45 mg, 0.16 mmol), acetic anhydride (16 μL, 0.16 mmol), and triethylamine (66 μL, 0.48 mmol) were dissolved in 1,2-dichloroethane (2 mL), and stirred for 30 min at room temperature. The reaction was quenched with H2O, and the resulting material was filtered through an Extrelut column. The Extrelut column was washed with EtOAc, and the filtrate was concentrated. The crude material was purified via Biotage eluting with a gradient of 0 to 10% MeOH in DCM. Lyophilization of the purified product provided 62 (7 mg, 13% yield) as a oily residue. LC-MS (M+H=325, obsd.=325).

1. customThe reaction was quenched with H2O
2. filtrationthe resulting material was filtered through an Extrelut column
3. washThe Extrelut column was washed with EtOAc
4. concentrationthe filtrate was concentrated
5. customThe crude material was purified via Biotage
6. washeluting with a gradient of 0 to 10% MeOH in DCM