Ethyl 4-bromobutyrate → HCID 68963617, compound

HRID 533803Notes

Reaction equation

HRID 533803 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH2:30][CH3:31])=[O:28]>CC#N>[Br-:23].[CH2:30]([O:29][C:27](=[O:28])[CH2:26][CH2:25][CH2:24][N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2)[CH3:31]

Participants

4

Reactant 2

HCID 76300Ethyl 4-bromobutyrateHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 68963617HCID 68963617, compoundYield 57.9%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0679 g, 0.231 mmol) and ethyl 4-bromobutanoate (0.055 mL, 0.524 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0637 g, 57.9%). EI-MS m/z 408(M+) Rt (1.80 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6bd0738086a746aca44a5be80b521787
Source dataset
uspto-grants-2014_10
Patent number
US08853404B2

Reaction notes

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