Phenethyl bromide → 4-[Hydroxy(di-2-thienyl)methyl]-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide

Participants

Reaction Steps

Following the general procedure outlined in Example 4, 1-azabicyclo[2.2.2]oct-4-yl(di-2-thienyl)methanol (0.0658 g, 0.215 mmol) and (2-bromoethyl)benzene (0.050 mL, 0.366 mmol) in 1MeOH/1 CHCl3 (4.0 mL) were reacted to give the desired product (0.051 4 g, 48.9%). EI-MS m/z 410(M+) Rt (1.83 min).

Provenance & Evidence