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1-(3-Bromopropoxy)-3-nitrobenzene → 4-[Hydroxy(diphenyl)methyl]-1-{3-[(3-nitrophenyl)oxy]propyl}-1-azoniabicyclo[2.2.2]octane bromide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Bromopropoxy)-3-nitrobenzene | HCID 7172301 | — |
| 反応物 | 1-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol | HCID 23992385 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-[Hydroxy(diphenyl)methyl]-1-{3-[(3-nitrophenyl)oxy]propyl}-1-azoniabicyclo[2.2.2]octane bromide | HCID 11570306 | 82.2% |
反応手順
Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0608 g, 0.207 mmol) and 3-bromopropyl 3-nitrophenyl ether (0.0730 g, 0.281 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0942 g, 82.2%). EI-MS m/z 474(M+) Rt (2.04 min).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853404B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-a17ec358a9cc4667b11ad2267218121a |
| 出典メモ | uspto-grants-2014_10 |