4-((5,6,7,8-Tetrahydro-8,8-dimethyl-5-oxonaphth-2-yl)ethynyl]benzoic acid → 4-[(5-Acetoxy-7,8-dihydro-8,8-dimethylnaphth-2-yl)ethynyl]benzoic acid

Participants

Reaction Steps

Employing the same general procedure as for the preparation of ethyl 4-[(5-acetoxy-7,8-dihydro-8,8-dimethylnaphth-2-yl)ethynyl]benzoate (Compound 105), 274 mg (0.86 mmol) of 4-[(5,6,7,8-tetrahydro-8,8-dimethyl-5-oxonapth-2-yl)ethynyl]benzoic acid (Compound 7) was converted into the title compound (light yellow solid) using 0.22 ml (2.58 mmol) acetic anhydride and 84 mg (0.43 mmol) of p-toluenesulfonic acid.

Provenance & Evidence