HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 86715088, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Reactant | (3S)-3-hydroxypyrrolidin-2-one | HCID 11029774 | — |
| Reactant | HCID 59089027 | HCID 59089027 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86715088 | HCID 86715088 | — |
Reaction Steps
A mixture of THF (200 mL) and DCM (100 mL) under argon was added triphenylphosphine (polymer, 1.8 mmol/g, 20 g). Diisopropylazodicarboxylate (8.87 g) was added. After 5 minutes (S)-3-hydroxy-pyrrolidin-2-one (3.1 g) and 6-(4-fluoro-phenoxy)-pyridin-3-ol (6.0 g) were added. After 30 minutes the mixture was filtered and the filtrate concentrated. The residue was purified by chromatography (SiO2; DCM/MeOH 15:1) to provide the title compound. MS ESI+: m/z=289 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853412B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-44a970d9f18146598afefcafcc02e40b |
| Source note | uspto-grants-2014_10 |