Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | HCID 86715100 | HCID 86715100 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86715099 | HCID 86715099 | — |
Reaction Steps
A mixture of (R)-3-(6-bromo-pyridin-3-yloxy)-pyrrolidin-2-one (0.8 g), sodium methanethiolate (327 mg) and DMF (15 mL) was heated to 100° C. for 15 minutes. After the mixture reached room temperature, it was distributed between water and EA. The organic phase was dried (Na2SO4) and concentrated. The residue was purified by preparative HPLC to provide the title compound. MS ESI+: m/z=225 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08853412B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-3a26957d90174e8c9cfbe03157da65eb |
|---|
| Source note | uspto-grants-2014_10 |
|---|
