Sodium 2-propanethiolate → HCID 86715102, compound

HRID 533911Notes

Reaction equation

HRID 533911 reaction equation
Br[C:2]1[N:7]=[CH:6][C:5]([O:8][C@@H:9]2[CH2:13][CH2:12][NH:11][C:10]2=[O:14])=[CH:4][CH:3]=1.[CH3:15][CH:16]([S-:18])[CH3:17].[Na+]>>[CH:16]([S:18][C:2]1[N:7]=[CH:6][C:5]([O:8][C@@H:9]2[CH2:13][CH2:12][NH:11][C:10]2=[O:14])=[CH:4][CH:3]=1)([CH3:17])[CH3:15]

Participants

3

Reactant 2

HCID 3470666Sodium 2-propanethiolateHCID 86715100HCID 86715100, compound

Product 1

HCID 86715102HCID 86715102, compound

Procedure

Typical Procedure 8 was followed. Reaction of (R)-3-(6-bromo-pyridin-3-yloxy)-pyrrolidin-2-one with sodium 2-propanethiolate provided the title compound. MS ESI+: m/z=253 [M+H]+.

Sources & evidence

ORD record
ord-0dd2129ab2204943ac57c8bfd7df233a
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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