Lithium borohydride → HCID 86715103, compound

Participants

Reaction Steps

To a solution of (R)-methyl 2-(5-(2-oxopyrrolidin-3-yloxy)pyridin-2-yl)thiazole-5-carboxylate (360 mg) in THF (5 mL) was added LiBH4 (100 mg) at 0° C. under nitrogen atmosphere. The reaction mixture was stirred at room temperature for 12 hours. After cooling to 0° C., the reaction was quenched by dropwise addition of water (until no more gas was generated). The reaction mixture was diluted with ethyl acetate (50 mL). The organic layer was washed with water (30 mL×2) and brine (20 mL) and dried over anhydrous Na2SO4. After filtration and evaporation of the solvent, the residue obtained was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (4:1 to pure EA) to afford the title compound. MS ESI+: m/z=292 [M+H]+.

Provenance & Evidence