Thionyl Chloride → HCID 58950926, compound

Participants

Reaction Steps

To a solution of 3-(4-bromo-2-fluoro-5-methylphenyl)propanoic acid (EP1795524 A1; 8.4 g) in DCM (200 mL) was added SOCl2 (19.1 g) dropwise at r.t. The mixture was stirred for 2 hours at r.t. The solvent was removed under reduced pressure. AlCl3 (21.4 g) was added to the residue. The brown slurry was heated to 130° C. for 1.5 hours and then cooled to r.t. The residue was dissolved in EA (300 mL) and then washed with water and brine. The organic phase was dried over Na2SO4. The residue obtained after filtration and evaporation was purified by SGC (PE/EA 400:1) to provide the title compound. MS ESI+: m/z=243 [M+H]+.

Provenance & Evidence