反应详情

温度

80 °C

A mixture of 6-bromo-4-fluoro-indan-1-one (Enamine, 453 mg), (S)-3-hydroxy-pyrrolidin-2-one (200 mg) and 1,4-dioxane (3 mL) was purged with argon. Cesium carbonate (645 mg), N,N′-dimethyl-ethylene-diamine (2.24 mL) and copper(I) iodide (38 mg) were added and the mixture was heated to 80° C. for 3 hours. After cooling to r.t. the mixture was filtered and the filtrate evaporated. The residue was purified by SGC (eluent: heptane/EA 1:1 with 0 to 20% MeOH) to provide the title compound. MS ESI+: m/z=250 [M+H]+.

1. customwas purged with argon
2. additionCesium carbonate (645 mg), N,N′-dimethyl-ethylene-diamine (2.24 mL) and copper(I) iodide (38 mg) were added
3. temperatureAfter cooling to r.t. the mixture
4. filtrationwas filtered
5. customthe filtrate evaporated
6. customThe residue was purified by SGC (eluent: heptane/EA 1:1 with 0 to 20% MeOH)