HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 533925Generated: October 25, 2026
Dimethyl Sulfoxide → 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol
https://huagongshe.com/reaction/533925
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| Reactant | HCID 178449908 | HCID 178449908 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(3-Isopropyl-[1,2,4]oxadiazol-5-yl)-pyridin-3-ol | HCID 136377300 | — |
Reaction Steps
To DMSO (25 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) and CDI (1.3 g). After 15 minutes N-hydroxy-isobutyramidine (820 mg) was added. After 1 hour the mixture was heated to 90° C. for 1 hour. After the mixture reached room temperature, it was diluted with EA and washed three times with HCl (0.1 M). The organic phase was dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=206 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08853412B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-989f920584734f61b7577085f4131722 |
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| Source note | uspto-grants-2014_10 |
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