HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanemethanol → HCID 86715115, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86715115 | HCID 86715115 | — |
Reaction Steps
To DMF (10 mL) was added 5-hydroxy-pyridine-2-carboxylic acid (1.0 g) followed by EDC (1.38 g), HOBt (971 mg) and DIPEA (1.22 mL). After 15 minutes cyclopropyl-methanol (520 mg) was added. After 12 hours the mixture was diluted with water and extracted three times with EA. The combined organic phases were washed with brine, dried (Na2SO4) and concentrated to provide the title compound. MS ESI+: m/z=194 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853412B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-59713c3d604049228389085ec6c7dc2c |
| Source note | uspto-grants-2014_10 |