5-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridine → 6-Cyclopropylmethoxy-5-fluoro-pyridin-3-ol

HRID 533930Notes

Reaction equation

HRID 533930 reaction equation
Br[C:2]1[CH:3]=[C:4]([F:13])[C:5]([O:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1.B([O-])[O-:15]>>[CH:10]1([CH2:9][O:8][C:5]2[N:6]=[CH:7][C:2]([OH:15])=[CH:3][C:4]=2[F:13])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 867151175-Bromo-2-(cyclopropylmethoxy)-3-fluoropyridineHCID 178514824HCID 178514824, compound

Product 1

HCID 867151166-Cyclopropylmethoxy-5-fluoro-pyridin-3-ol

Procedure

Following Typical Procedures 4 and 5a, conversion of 5-bromo-2-cyclopropylmethoxy-3-fluoro-pyridine to the boronate and oxidation with NaBO3 provided the title compound.

Sources & evidence

ORD record
ord-ea9705a197124180994f19bc58685b20
Source dataset
uspto-grants-2014_10
Patent number
US08853412B2

Reaction notes

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