HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphenylacetic Acid → HCID 86600157, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphenylacetic Acid | HCID 8333 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl (2-amino-1,3-thiazol-4-yl)acetate | HCID 738059 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86600157 | HCID 86600157 | — |
Reaction Steps
(2-Amino-thiazol-4-yl)-acetic acid methyl ester (45 mg, 0.20 mmol) and diphenyl-acetic acid (37 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (2 mL) containing triethylamine (84.1 μL, 0.600 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (84 mg, 0.22 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography (29.4 mg, 0.0802 mmol, 40. %). ESI-MS m/z calc. 380.1. found 381.3 (M+1)+ Retention time 3.28 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853415B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-c51d2dc4a98f473a94be759a66888427 |
| Source note | uspto-grants-2014_10 |