HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenylbutyric Acid → HCID 58032991, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenylbutyric Acid | HCID 7012 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 57456945 | HCID 57456945 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58032991 | HCID 58032991 | — |
Reaction Steps
5-(2-Chloro-benzyl)-1-methyl-1H-imidazol-2-ylamine (44 mg, 0.20 mmol) and 2-phenyl-butyric acid (33 mg, 0.20 mmol) were dissolved in N,N-dimethylformamide (1 mL) containing triethylamine (84.1 μL, 0.600 mmol). O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (84 mg, 0.22 mmol) was added and the solution was allowed to stir for 16 hours. The crude product was purified by reverse-phase preparative liquid chromatography (13 mg, 0.035 mmol, 18%). ESI-MS m/z calc. 367.2. found 368.1 (M+1)+ Retention time 2.42 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853415B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-0fb58837e19640a7a9a50e8936f7c5b2 |
| Source note | uspto-grants-2014_10 |