Benzoyl chloride → HCID 4683419, compound

HRID 533980Notes

Reaction equation

HRID 533980 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1.[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([NH:14][C:15](=[O:22])[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[S:12][CH:13]=1

Participants

4

Reactant 2

HCID 7412Benzoyl chlorideHCID 7352524-(2-Methoxy-phenyl)-thiazol-2-ylamine

Product 1

HCID 4683419HCID 4683419, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

4-(2-Methoxy-phenyl)-thiazol-2-ylamine (41.3 mg, 0.200 mmol) and benzoyl chloride (28.1 mg, 0.200 mmol) were dissolved in 1 mL of pyridine. The reaction mixture was stirred at room temperature overnight and then purified by reverse-phase preparative liquid chromatography (11.4 mg, 0.0367 mmol, 18.4%). ESI-MS m/z calc. 310.1. found 311.2 (M+1)+ Retention time 3.55 minutes.

Workup

  1. custompurified by reverse-phase preparative liquid chromatography (11.4 mg, 0.0367 mmol, 18.4%)

Sources & evidence

ORD record
ord-b793ac1bbb6b4da39ab7c94f6963b8cc
Source dataset
uspto-grants-2014_10
Patent number
US08853415B2

Reaction notes

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