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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 5341Generated: October 28, 2026

Methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate → HCID 178418571, compound

https://huagongshe.com/reaction/5341

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylateHCID 19013272—
ReactantHCID 178418575HCID 178418575—
Solvent1-ButanolHCID 263—
ProductHCID 178418571HCID 178418571—

Reaction Steps

1.89 g of (4.5 mmols) of methyl 2-[[3-[4-(5-chloro-2-methoxyphenyl)piperazin-1-yl]propyl]amino]-pyrimidine-4-carboxylate and 0.77 g (5 mmols) of 2-[(2-aminoethyl)amino]pyrimidin-4(1H)-one in 5 ml of n-butanol are introduced into a 25 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 15 hours and then the solvent is evaporated under reduced pressure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05244894
Source datasetuspto-grants-1993_09
ORD IDord-682b7c7c9d9d4c65b29faad31f704d69
Source noteuspto-grants-1993_09