Chlorosulfonic acid → HCID 54595979, compound

HRID 534143Notes

Reaction equation

HRID 534143 reaction equation
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[Cl:12][S:13](O)(=[O:15])=[O:14]>>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][C:3]=1[S:13]([Cl:12])(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 27732896-bromo-2,3-dihydro-1H-indol-2-one

Product 1

HCID 54595979HCID 54595979, compound

Conditions

Temperature
0 °C

Procedure

Chlorosulphonic acid (30 mL) is taken, cooled to 0° C. cooled and combined with 8 g of 6-bromoindolinone with vigorous stirring. The ice bath is removed and the mixture is stirred for a further 16 h at RT. The reaction mixture is slowly poured onto ice with vigorous stirring, the precipitate formed is filtered off and dried in the vacuum dryer. 6-Bromindolinone-5-sulphonyl chloride is obtained as crude product, which is further used directly.

Workup

  1. temperaturecooled
  2. customThe ice bath is removed
  3. additionThe reaction mixture is slowly poured onto ice with vigorous stirring
  4. customthe precipitate formed
  5. filtrationis filtered off
  6. customdried in the vacuum dryer

Sources & evidence

ORD record
ord-e156e215917b4c1681052d97095119c9
Source dataset
uspto-grants-2014_10
Patent number
US08853420B2

Reaction notes

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