HCID 19795851, compound → HCID 178418599, compound

HRID 5342Notes

Reaction equation

HRID 5342 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:27][CH3:28])=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]3[N:22]=[C:21]([C:23](OC)=[O:24])[CH:20]=[CH:19][N:18]=3)[CH2:10][CH2:9]2)[CH:7]=1.[NH2:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]1[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=1>C(O)CCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:27][CH3:28])=[C:6]([N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][NH:16][C:17]3[N:22]=[C:21]([C:23]([NH:29][CH2:30][CH2:31][CH2:32][NH:33][C:34]4[NH:35][CH:36]=[CH:37][C:38](=[O:40])[N:39]=4)=[O:24])[CH:20]=[CH:19][N:18]=3)[CH2:12][CH2:13]2)[CH:7]=1

Participants

4

Reactant 2

HCID 19795851HCID 19795851, compoundHCID 178418669HCID 178418669, compound

Product 1

HCID 178418599HCID 178418599, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

3.0 g (7.4 mmols) of methyl 2-[[2-[4-(5-chloro-2-methoxyphenyl)piperazin- 1-yl]ethyl]amino]-pyrimidine-4-carboxylate and 1.5 g (8.9 mmols) of 2-[(3-aminopropyl)amino]pyrimidin-4(1H)-one in 20 ml of n-butanol are introduced into a 100 ml, round bottomed flask. The mixture is heated at the reflux temperature of the solvent for 20 hours and then the solvent is evaporated under reduced pressure.

Workup

  1. temperatureThe mixture is heated at the reflux temperature of the solvent for 20 hours
  2. customthe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-61c8410b006347f6bdbec94f311bc8c4
Source dataset
uspto-grants-1993_09
Patent number
US05244894

Reaction notes

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