Trifluoroacetic acid → HCID 86708247, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(2-(2,2,2-trifluoro-N-(trans-2-phenylcyclopropyl)acetamido)ethyl)piperidine-1-carboxylate (650 mg, 1.476 mmol) in dichloromethane (DCM) (4 mL) was added TFA (1 mL, 12.98 mmol), and the mixture was stirred at room temperature for 1.5 h. The mixture was concentrated and the residue was dissolved in DCM (20 mL). The resulting solution was washed with 10% NaHCO3 aqueous solution. The organic phase was collected and dried (Na2SO4) and concentrated. The residue was dried under vacuum to give 470 mg of product as oil. MS: (M+H)+=341.4. 1H NMR (400 MHz, METHANOL-d4) δ ppm 1.33-1.79 (m, 7H), 1.93-2.10 (m, 2H), 2.27-2.59 (m, 1H), 2.84-3.06 (m, 2H), 3.15-3.25 (m, 1H), 3.66 (t, J=7.20 Hz, 2H), 7.09-7.41 (m, 5H).

Provenance & Evidence