HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dichloroaniline → (2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dichloroaniline | HCID 7257 | — |
| Reactant | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| Product | (2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine | HCID 22060411 | — |
Reaction Steps
In like manner to the preparation of 2-chloro-5-fluoro-N4-[3-(1H-tetrazol-5-yl)phenyl]-4-pyrimidineamine the reaction of 2,4-dichloro-5-fluoropyrimidine with 3,4-dichloroaniline gave 2-chloro-N4-(3,4-dichlorophenyl)-5-fluoro-4-pyrimidineamine. LCMS: purity: 95%; MS (m/e): 294 (M+2H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08853397B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-5f3c7647da44497c9de8ba924aee9717 |
| Source note | uspto-grants-2014_10 |