Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Tert-Butylaniline → N2,N4-bis(4-tert-butylphenyl)-5-fluoro-2,4-pyrimidinediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Tert-Butylaniline | HCID 69861 | — |
| 반응물 | 2,4-Dichloro-5-fluoropyrimidine | HCID 250705 | — |
| 생성물 | N2,N4-bis(4-tert-butylphenyl)-5-fluoro-2,4-pyrimidinediamine | HCID 22060893 | — |
반응 단계
In like manner to the preparation of N2,N4-bis(3-hydroxyphenyl)-5-fluoro-2,4-pyrimidinediamine, 2,4-dichloro-5-fluoropyrimidine and 4-tert-butylaniline were reacted to yield N2,N4-bis(4-tert-butylphenyl)-5-fluoro-2,4-pyrimidinediamine. 1H NMR (CDCl3): δ 7.77 (d, 1H, J=3.9 Hz), 7.47 (d, 2H, J=9 Hz), 7.38 (m, 4H), 7.30 (d, 2H, J=8.7 Hz), 1.34 (s, 9H), 1.32 (s, 9H); LCMS: ret. time: 34.09 min.; purity: 93%; MS: 393 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08853397B2 |
| 출처 데이터셋 | uspto-grants-2014_10 |
| ORD ID | ord-d80297939c4c4914844eac7890489d25 |
| 출처 메모 | uspto-grants-2014_10 |